Chitosan (Deacetylated chitin) (Deacetylated chitin) is a polycationic linear polysaccharide derived from chitin.
Chitosan is a natural polycationic linear polysaccharide derived from chitin.
Chitosans, chemically defined as deacetylated chitin, are recognized as versatile biomaterials because of their non-toxicity, low allergenicity, biocompatibility, and biodegradability. Chitosan is reported to have other biological properties, such as antitumor, antimicrobial, and antioxidant activities. It can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity treatment and as a scaffold for tissue engineering[1]. Antimicrobial activity of chitosan has been demonstrated against many bacteria, filamentous fungi and yeasts. Chitosan has wide spectrum of activity and high killing rate against Gram-positive and Gram-negative bacteria, but lower toxicity toward mammalian cells[2]. Chitosan exhibits antitumor activity against different types of cancer. For example, chitosan decreases adhesion of primary melanoma A375 cell line and decreases proliferation of primary melanoma SKMEL28 cell line, it has potent pro-apoptotic effects against RPMI7951, a metastatic melanoma cell line[3]. Chitosan and its derivatives act as antioxidants by scavenging oxygen radicals such as hydroxyl, superoxide, alkyl as well as highly stable DPPH radicals in vitro[4].
Chitosan treatment dramatically increases lifespan and inhibits tumor metastasis especially in treatment groups of the low-molecular weight compound[5]. Chitosan has some apparent treatment effects on rat PCP by reducing HSP70 mRNA expression and lung inflammation, increasing the concentrations of IL-10 and IFN-γ as well as CD4(+) T-lymphocyte numbers, reducing the CD8(+) T-lymphocyte numbers and the concentration of TNF-α and inducing significant ultrastructural damage to P. carinii[6].
[1]. Cheung RC, et al. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications. Mar Drugs. 2015 Aug 14;13(8):5156-86. [2]. Kong M, et al. Antimicrobial properties of chitosan and mode of action: a state of the art review. Int J Food Microbiol. 2010 Nov 15;144(1):51-63. [3]. Gibot L, et al. Anticancer properties of chitosan on human melanoma are cell line dependent.Int J Biol Macromol. 2015 Jan;72:370-9. [4]. Younes I, et al. Chitin and chitosan preparation from marine sources. Structure, properties and applications. Mar Drugs. 2015 Mar 2;13(3):1133-74. [5]. Yeh MY, et al. Effects of chitosan on xenograft models of melanoma in C57BL/6 mice and hepatoma formation in SCID mice. Anticancer Res. 2013 Nov;33(11):4867-73. [6]. Liu AB, et al. Therapeutic efficacies of chitosan against Pneumocystis pneumonia of immunosuppressed rat. Parasite Immunol. 2014 Jul;36(7):292-302
[2].
|
[3]. Cas No. |
[4]. 9012-76-4 |
[5]. SDF |
[6]. |
|
[7]. Canonical SMILES |
[8]. O[C@H]1[C@H](O)[C@@H](N)[C@H](O[C@H]2[C@H](O)[C@@H](N)[C@H](O[C@H]3[C@H](O)[C@@H](N)[C@H](O)O[C@@H]3CO)O[C@@H]2CO)O[C@@H]1CO.[n] |
||
|
[9]. Formula |
[10]. (C6H13NO5)n |
[11]. M.Wt |
[12]. 161.16(monomer) |
|
[13]. Solubility |
[14]. Water : 0.67 mg/mL (ultrasonic and adjust pH to 3 with HCl);Water : < 0.1 mg/mL (insoluble);DMSO : < 1 mg/mL (insoluble or slightly soluble) |
[15]. Storage |
[16]. Store at -20°C |
|
[17]. General tips |
[18]. Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. |
||
|
[19]. Shipping Condition |
[20]. Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
|
||
