Overdose symptoms
- from the central nervous system: drowsiness, stupor, coma, ataxia, hallucinations, anxiety, psychomotor agitation, decreased ability to concentrate, disorientation, confusion, dysarthria, hyperreflexia, muscle stiffness, choreoathetosis, epileptic syndrome.
- on the part of the CCC: decreased blood pressure, tachycardia, arrhythmia, impaired intracardiac conduction, ECG changes (especially QRS) characteristic of toxicity to tricyclic antidepressants, shock; in very rare cases - cardiac arrest.
- others: respiratory depression, shortness of breath, cyanosis, vomiting, hyperthermia, mydriasis, increased sweating, oliguria or anuria.
Symptoms develop 4 hours after an overdose, reach a maximum after 24 hours and last 4-6 days. If an overdose is suspected, especially in children, the patient should be hospitalized..
Children are more sensitive to acute overdose, which should be considered dangerous and potentially fatal to them..
Contraindications
Contraindications to the use of amitriptyline tablets:
- Hypersensitivity to the components of the drug;
- Myocardial infarction (acute phase and rehabilitation period);
- Use in the 2 weeks prior to treatment, antidepressants (MAO inhibitors);
- Arterial hypertension;
- BPH;
- Pyloric stenosis;
- Heart failure (decompensation stage);
- Blockade of the heart (violation of intracardiac conduction);
- Atony of the bladder;
- Intestinal obstruction;
- Children's age up to 6 years;
- Pregnancy and lactation;
- Renal and liver failure.
Destination restrictions
It is forbidden to take amitriptyline tablets with:
- individual immunity of the body to the components of the composition of the drug;
- acute alcohol intoxication;
- drug intoxication;
- myocardial infarction;
- angle-closure glaucoma;
- breastfeeding;
- children under 6 years old.
It is prescribed with caution to patients in the following cases:
- with chronic alcoholism;
- with bronchial asthma;
- with schizophrenia;
- with bipolar disorder;
- with epilepsy;
- with oppressed hematopoiesis;
- with angina pectoris;
- with heart failure of a chronic form;
- with arrhythmia;
- with hypertension;
- with reduced motor function of the gastrointestinal tract;
- with diseases of the thyroid gland;
- with renal and liver failure;
- with prostatic hyperplasia;
- with hypotension of the bladder;
- with urinary retention.
For women during pregnancy (especially in the first trimester), amitriptyline tablets are prescribed in the minimum dosage, therapy should be accompanied by constant medical supervision.
Overdose
The main symptoms of an overdose are hallucinations, convulsions, coma, cardiac conduction disturbance, extrasystole, ventricular arrhythmia, hypothermia.
It is recommended to wash the stomach, take a suspension of activated carbon, laxatives, fluid infusion, symptomatic therapy, maintain body temperature, monitor the function of the cardiovascular system for at least 5 days, because relapse can occur after 48 hours or later. Hemodialysis and forced diuresis are ineffective.
Contraindications
The use of amitriptyline (order Amitriptyline tablets) is contraindicated in patients suffering from: decompensated heart disease, impaired cardiac conduction, acute or recovery period of myocardial infarction, atony of the bladder, acute diseases of the kidneys and liver, stomach ulcer or duodenal ulcer in the acute stage, glaucoma, blood diseases, impaired urinary function hypertrophy of the prostate, paralytic bowel obstruction. The use of amitriptyline in combination with monoamine oxidase inhibitors, people with hypersensitivity to the components of the drug, and women during pregnancy or breastfeeding is not recommended. With caution, the drug is prescribed to people suffering from alcoholism, asthma, manic-depressive psychosis, epilepsy, angina pectoris, schizophrenia, hyperthyroidism, intraocular hypertension.
Solution for intravenous and intramuscular administration
1 ml of solution contains:
The active substance is amitriptyline hydrochloride equivalent to 10.0 mg of amitriptyline - 11.31 mg.
- dextrose monohydrate in terms of dextrose - 40.0 mg,
- sodium chloride - 2.6 mg,
- benzetonium chloride - 0.1 mg,
- hydrochloric acid or sodium hydroxide - up to pH 4.0 - 6.0,
- water for injection - up to 1 ml.