Researchers at Stanford University recently said they have developed a gene therapy new technology without the viral vector , which is expected to enhance the safety of gene therapy. The so-called gene therapy, it simply refers to a gene treatment that use normal gene to replace the defective gene or gene mutation in human body . In the process of implementing gene therapy, a normal gene should be transferred into the cells through a necessary carrier, so as to achieve therapeutic purposes. The carrier is currently more popular through the transformation of the harmless virus, but some studies have shown that viral vectors will sometimes send the wrong part of the normal gene, which may activate certain oncogenes, bring unexpected dangerous effects .
In order to improve the safety of gene therapy, many scientists are actively looking for alternative viral gene delivery vehicles, such as Stanford University School of Medicine, Dr. Carlo developed a new technology borrowed from phage infection mechanism. Phage can be infected with a virus and can destroy bacteria, it is mainly through an integrase enzyme, his genes into the chromosome of bacterial infections on the particular DNA (deoxyribonucleic acid) fragment.
Carlo, who found that other animals and humans, there are also similar DNA fragments could be to target the integrase enzyme at the time of the inserted gene. When they injected the mice experiment to encode "IX factor" genes. "IX Factor" is a blood clotting protein, human Without it will suffer from hemophilia. At the same time, the researchers also injected some mice in vivo gene encoding integrase enzyme and found that, in less than a week, two genes into the mice, the body "IX factor" content, those injected only 12 times a gene "IX factor" of mice. Further studies confirmed that accepted the two genes into the mice, the body's "IX factor" gene successful combination of genes and their body as a whole.
Dr. Carlo said they developed new technology for gene therapy offers a new choice in the treatment of skin, retina, muscle and other tissue diseases may all have potential applications. If you are interested in more info about gene therapy technology , please refers to this site http://www.bioabb.com/products/Human-APP-Primer-Pair-6.html .