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Reductions in orbital fat (i.e., fat around the eye) have been observed in patients using bimatoprost as glaucoma therapy.[11] Of particular interest, the loss of orbital fat was unilateral in patients who used bimatoprost on only one eye.[12] The effect appears reversible upon cessation of bimatoprost use.[citation needed] The effect is likely to explain deepening of the lid sulcus described in a series of three patients on bimatoprost.[13] The mechanism for the apparent fat reduction remains unclear. However, bimatoprost is chemically analogous to prostaglandin F2? (PGF2?), a compound which is known to reduce fat by inhibition of adipocyte differentiation and survival.[14]

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