BCP0001/GDC-0941,GDC0941/
Brand Name :Biochempartner
M.Wt:705.83 Formula: C23H27N7O3S2.2CH3SO3H
Solubility: Soluble in DMSO
Purity: 99% Storage: -20C 2 years
Appearance:white solid 10G in stock
CAS No: 957054-30-7
Bulk Order Enquiry GDC0941-NMR GDC0941-LCMS Purchase price Yen price:lowest price for bulk quantity Dollar price:5mg 150USD 10mg 250USD Customer Feed Back: Goods Reviews: We tested your GDC0941 side by side with that from India by LC-MS analysis and the results show both products are very pure and almost the same. I just received GDC0941. It's pretty fast. Thank you so much! I will definitely take your company as my first choice next time when I order bulk sized inhibitors. Hailing/Dana Farber Cancer Institute Biological Activity: 1.The IC50 values of GDC0941 for the inhibition of phosphorylation of Ser473 on AKT in IGROV-1 cells following 2- or 8-hour exposure were 18 ± 1 and 38 ± 13 nmol/L, respectively. 2.GDC-0941 Causes Sustained Inhibition ofthe Phosphatidylinositide 3-Kinase Pathway in U87MG Glioblastoma Xenografts 3.GDC-0941 was much less potent on mTOR and DNA-PK. Importantly, the activity of GDC-0941 against the panel of human tumor cell lines was generally similar to that of PI-103, suggesting that high potency against mTOR and/or DNA-PK was not essential for the inhibition of cell proliferation. In addition,GDC-0941 potently inhibited growth of activated human endothelial cells, suggesting potential for antiangiogenic activity, as we previously reported for PI-103. References: 1.Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
連絡担当：王燕 skype:wangyan1234563939
Tel:+815055348427
E-mail:yanweipx@139.com chunfang@biochempartner.com
ホームページ：www.biochempartner.com