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A Karger 'Publishing Highlights 1890�' title Drug hypersensitivities are immune-mediated reactions characterized by exanthems, fever and internal organ involvement. They represent a challenging field of research: many different drugs can induce a variety of clinical symptoms through multiple mechanisms of drug-host interaction, many of which are poorly understood. This is the first book to approach the phenomenon of drug hypersensitivity in a comprehensive manner. Besides epidemiological aspects, it addresses the immunological mechanisms underlying these complicated reactions which go far beyond the IgE-mediated drug allergies also considered in the book. Furthermore, the book covers clinical manifestations and new diagnostic methods, and introduces some recently established animal models. Well-accepted and also completely new concepts are presented and discussed in detail. Many topics are treated from multiple perspectives, and the 33 chapters are thoroughly
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