Emerging anticancer potential and mechanisms of snake venom toxins: A review
X Guo, Y Fu, J Peng, Y Fu, S Dong, RB Ding, X Qi… - International Journal of …, 2024
Animal-derived venom, like snake venom, has been proven to be valuable natural
resources for the drug development. Previously, snake venom was mainly
investigated in its pharmacological activities in regulating coagulation, vasodilation,
and cardiovascular function, and several marketed cardiovascular drugs were
successfully developed from snake venom. In recent years, snake venom fractions
have been demonstrated with anticancer properties of inducing apoptotic and …
resources for the drug development. Previously, snake venom was mainly
investigated in its pharmacological activities in regulating coagulation, vasodilation,
and cardiovascular function, and several marketed cardiovascular drugs were
successfully developed from snake venom. In recent years, snake venom fractions
have been demonstrated with anticancer properties of inducing apoptotic and …
| • | 引用: A platform of C-type lectin-like receptor CLEC-2 for binding O …  |
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[PDF] Morphological Study for the Osteocytes in Podoplanin-Conditional Knockout Mice
大澤杏子 - 2024
We generated podoplanin-conditional knockout mice where the floxed podoplanin
exon3 was deleted by the Dmp-1-driven Cre (Dmp1-Cre; PdpnΔ/Δ) and investigated
the cell process elongation of podoplanin-deficient mouse osteocyte in vitro and in
vivo. The expression of podoplanin is found in odontoblasts while not observed in
odontoblasts of Dmp1-Cre; PdpnΔ/Δ mice, indicating that the conditional knockout of
podoplanin in Dmp1-expressing cells in Dmp1-Cre; PdpnΔ/Δ mice is successful …
exon3 was deleted by the Dmp-1-driven Cre (Dmp1-Cre; PdpnΔ/Δ) and investigated
the cell process elongation of podoplanin-deficient mouse osteocyte in vitro and in
vivo. The expression of podoplanin is found in odontoblasts while not observed in
odontoblasts of Dmp1-Cre; PdpnΔ/Δ mice, indicating that the conditional knockout of
podoplanin in Dmp1-expressing cells in Dmp1-Cre; PdpnΔ/Δ mice is successful …
| • | 引用: Morphological study of tooth development in podoplanin-deficient …Proteomic Characterization of Undifferentiated Small Round Cell Sarcomas with EWSR1-and CIC:: DUX4-Translocations Reveals Diverging Tumor Biology and …S Doll, L Schweizer, C Bollwein, K Steiger, N Pfarr… - Modern Pathology, 2024
Undifferentiated small round cell sarcomas of bone and soft tissue (USRS) are a
group of tumors with heterogenic genomic alterations sharing similar morphology. In the present study, we performed a comparative large-scale proteomic analysis of USRS (n= 42) with diverse genomic translocations including classic Ewing sarcomas with EWSR1:: FLI1 fusions (n= 24) or EWSR1:: ERG–fusions (n= 4), sarcomas with an EWSR1–rearrangement (n= 2), CIC:: DUX4 fusion (n= 8), as well as tumors …
[HTML] Serum klotho associated with thyroid hormone in adults: A population-based cross-sectional researchX Zhang, X Liu, L Li, Y Zhang, Q Li, H Geng, L Shi… - PloS one, 2024
Background and study aim The klotho protein, a multifunctional protein, has been
shown to be associated with a wide range of endocrine diseases and has been linked to thyroid tumourigenesis. However, the relationship between serum klotho levels and thyroid hormones remains poorly understood. This study aimed to explore the correlation between serum klotho levels and thyroid hormones. Methods Data was obtained from the NHANES cycles 2007–2008, 2009–2010, and 2011–2012. A …
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