Multifunctional Magnetic CuS/Gd2O3 Nanoparticles for Fluorescence/Magnetic Resonance Bimodal Imaging-Guided Photothermal-Intensified Chemodynamic …
M Luo, H Yukawa, K Sato, M Tozawa, M Tokunaga… - ACS Applied Materials & …, 2022
Chemodynamic therapy (CDT), which consumes endogenous hydrogen peroxide
(H2O2) to generate reactive oxygen species (ROS) and causes oxidative damage to
tumor cells, shows tremendous promise for advanced cancer treatment. However,
the rate of ROS generation based on the Fenton reaction is prone to being restricted
by inadequate H2O2 and unattainable acidity in the hypoxic tumor
microenvironment. We herein report a multifunctional nanoprobe (BCGCR) …
(H2O2) to generate reactive oxygen species (ROS) and causes oxidative damage to
tumor cells, shows tremendous promise for advanced cancer treatment. However,
the rate of ROS generation based on the Fenton reaction is prone to being restricted
by inadequate H2O2 and unattainable acidity in the hypoxic tumor
microenvironment. We herein report a multifunctional nanoprobe (BCGCR) …
| • | 引用: Targeted phototherapy for malignant pleural mesothelioma: near …  |
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The neural basis of sugar preference
WW Liu, DV Bohórquez - Nature Reviews Neuroscience, 2022
When it comes to food, one tempting substance is sugar. Although sweetness is
detected by the tongue, the desire to consume sugar arises from the gut. Even when
sweet taste is impaired, animals can distinguish sugars from non-nutritive
sweeteners guided by sensory cues arising from the gut epithelium. Here, we review
the molecular receptors, cells, circuits and behavioural consequences associated
with sugar sensing in the gut. Recent work demonstrates that some duodenal cells …
detected by the tongue, the desire to consume sugar arises from the gut. Even when
sweet taste is impaired, animals can distinguish sugars from non-nutritive
sweeteners guided by sensory cues arising from the gut epithelium. Here, we review
the molecular receptors, cells, circuits and behavioural consequences associated
with sugar sensing in the gut. Recent work demonstrates that some duodenal cells …
| • | 引用: Structural basis for perception of diverse chemical substances by … |
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[HTML] Podoplanin expression in lymph node metastases of head and neck cancer and cancer of unknown primary patients
JP Kühn, F Bochen, S Körner, B Schick, M Wagner… - The International Journal of …, 2022
Introduction Head and neck squamous cell carcinomas (HNSCCs) are cancers with
generally poor prognosis. Outcomes have not improved in decades, with more than
half of the patients presenting with lymph node metastases at the time of diagnosis. A
unique subtype of HNSCC, cancer of unknown primary of the head and neck
(HNCUP) is associated with a poor outcome. Increased expression of the D2-40
gene (podoplanin) has been described for several human malignancies and has …
generally poor prognosis. Outcomes have not improved in decades, with more than
half of the patients presenting with lymph node metastases at the time of diagnosis. A
unique subtype of HNSCC, cancer of unknown primary of the head and neck
(HNCUP) is associated with a poor outcome. Increased expression of the D2-40
gene (podoplanin) has been described for several human malignancies and has …
| • | 引用: Increased expression of podoplanin in malignant astrocytic tumors … |