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Amoxicillin and TetracyclineRenal Impairment. Assess renal function periodically during prolonged therapy. The drug should be discontinued immediately at the first appearance of a skin rash or other signs of hypersensitivity. The rash is described as maculopapular or morbilliform (measles-like; therefore, in medical literature, it is called "amoxicillin-induced morbilliform rash"). It starts on the trunk and can spread from there. This rash is unlikely to be a true allergic reaction, and is not a contraindication for future amoxicillin usage, nor should the current regimen necessarily be stopped. However, this common amoxicillin rash and a dangerous allergic reaction cannot easily be distinguished by inexperienced persons, and therefore a healthcare professional is often required to distinguish between the two. 50 mg/kg as a single dose given 1 hour prior to the procedure for moderate-risk patients. For high-risk patients, give an initial IM or IV dose of ampicillin with IM or IV gentamicin within 30 minutes of starting the procedure followed by 25 mg/kg of amoxicillin 6 hours later.
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