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Amoxicillin alternativesIn the Collaborative Perinatal Project involving 50,282 mother-child pairs, there were 3,546 mother-child pairs exposed to penicillin derivatives in the first trimester. As a group, there was no significant increase in the risk of malformations. In the Michigan Medicaid Birth Defects Study involving 229,101 pregnancies from 1985 to 1992, there were 8,538 first trimester exposures to amoxicillin. Overall, 317 cases of birth defects were observed (363 expected). There was no evidence of an association between first trimester use of amoxicillin and major groups of malformations. A Danish study of 401 women exposed to amoxicillin during pregnancy from 1991 to 2000 did not find an increased risk of birth defects or adverse outcomes compared to women who had taken no medication. Transient decreases in total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol plasma concentrations have been reported in pregnant women who received ampicillin and this may also occur with amoxicillin. NURSING MOTHERS: Small amounts of amoxicillin may be excreted in breast milk and may cause diarrhea or allergic responses in nursing infants. Amoxicillin is generally considered safe to use while breastfeeding. Amoxicillin is used to treat infections in the newborn. Side effects: some of the possible side effects, which the antibiotic causes are nausea, antibiotic-associated colitis, rash, and vomiting. In rare cases, lightheadedness, anxiety, confusion, insomnia, unclear thinking, and sensitivity to sound or light could occur and if this happens, the patient should seek medical assistance at once. Adverse effects. Side-effects are as those for other beta-lactam antibiotics. Side-effects include nausea, vomiting, rashes, and antibiotic-associated colitis. Loose bowel movements (diarrhoea) may also occur. Rarer side-effects include mental changes, lightheadedness, insomnia, confusion, anxiety, sensitivity to lights and sounds, and unclear thinking. Immediate medical care is required upon the first signs of these side-effects.
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